BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Katerina Vrzalikova, Ciaran Bernard John Woodman, Paul Gerard Murray
2012 Biomedical Papers of the Faculty of Medicine of Palacky University  
Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of
more » ... e Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
doi:10.5507/bp.2012.003 pmid:22580854 fatcat:jyrg6bhzffdmbobigda67mhuci