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BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Katerina Vrzalikova, Ciaran Bernard John Woodman, Paul Gerard Murray
2012 Biomedical Papers of the Faculty of Medicine of Palacky University  

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Aims. The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of
more » ... e Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
doi:10.5507/bp.2012.003 pmid:22580854 fatcat:jyrg6bhzffdmbobigda67mhuci
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Katerina Vrzalikova, Ciaran Bernard John Woodman, Paul Gerard Murray. "BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas." Biomedical Papers of the Faculty of Medicine of Palacky University 156.1 (2012) 1-6