INTRARENAL HAEMODYNAMIC IN TYPE 2 DIABETIC S MELLITUS AND ITS CORRELATION WITH BIOCHEMICAL PARAMETERS
English

Thukral C L, Meenakshi Aggarwal, Nayyar S B
2015 Journal of Evolution of Medical and Dental Sciences  
AIMS & OBJECTIVES: The evaluation of resistance index of interlobar artery on Color Doppler imaging in type 2 diabetes mellitus patients and comparison with healthy controls and the Correlation among Colour Doppler sonographic findings and biochemical parameters in type 2 diabetic patients. MATERIALS AND METHODS: 200 patients with type 2 diabetes mellitus and 30 healthy controls were included in this study. The resistive index of interlobar renal arteries was used to assess the internal
more » ... he internal haemodynamic changes in diabetic patients as compared to normal subjects. RESULTS: The patients were divided into four groups: Group I: consisted of patients with 24 hour urinary protein less than 30 mg per ml; Group II: 30 to 300 mg per ml, Group III: more than 300 mg per ml and Group IV: serum creatinine more than or equal to 1.5mg per dl. The mean of intrarenal RI value was 0.66+.21 in controls, 0.69.42 in group I, 0.72.24 in group II, 0.76.34 in group III and 0.84.35 in group IV. RI values in group II, III and IV were significantly higher than those in controls (p<.0.001). And those in group IV were significantly higher than those in group I, II and III. Also, there was a significant effect of duration of diabetes on intra renal hemodynamics with mean RI value 0.72+0.43 in patients with diabetes of less than 10 year duration and mean RI value of 0.78.0.34 in patients with diabetes more than 10 year duration. CONCLUSION: Type 2 diabetic patients have higher values of RI as compared to non-diabetics and this increment is proportional to the duration of diabetes. An intra renal RI value of >0.7 identifies diabetic patients at risk of progressive renal disease. Higher RI correlates to higher protein in urine and duration of diabetes in diabetic patients. Thus, an increasing intra-renal resistance index value could prompt the physician to a more tight control of blood sugars and hypertension in the group of diabetic patients, delaying the progression to end stage renal failure.
doi:10.14260/jemds/2015/928 fatcat:srofqgf24banbbgzw75hdfnwha