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Sequences surrounding the miRNA binding domain of the miRNA inhibitor LidNA were selected intracellularly. The library was transfected into cells, and then, inhibitors that were associated with argonaute 2 were selected. The potent inhibitors were slowly degraded intracellularly, while the lower-activity inhibitors were rapidly degraded. A combination of the selected sequences surrounding the miRNA binding domain enhanced miRNA inhibitory activity. Abbreviations: LidNA: DNA that puts a lid ondoi:10.6084/m9.figshare.11992965 fatcat:tjswgxltg5gwfhu42bp5apazzq