How MicroRNAs Modify Protein Production

Jessica L Feig, Keith M Giles, Iman Osman, Andrew G Franks
2015 Journal of Investigative Dermatology  
OVERVIEW It is generally accepted that the flow of genetic information from genomic DNA to functional protein is not unidirectional and linear. Rather, numerous molecular pathways regulate the processes of replication, transcription, and translation to fine-tune the output of protein-coding genes. Specifically, RNA interference is a biological process in which specialized small RNAs-short interfering RNAs (siRNAs) or microRNAs (miRNAs)-posttranscriptionally regulate the expression of specific
more » ... ssion of specific target genes. In the December 2013 Research Techniques Made Simple, Nambudiri and Widlund described siRNAs and applications in investigative dermatology (Nambudiri and Widlund, 2013) . Here, we outline how miRNAs modulate expression of genes relevant to skin pathology by inhibiting protein translation.
doi:10.1038/jid.2015.99 pmid:25882467 fatcat:6bitrmiidbaabbb6tsxzmd64xu