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Designed peptides may generate molecular scaffolds in the form of hydrogels to support tissue regeneration. We studied the effect of hydrogels comprising b-sheet-forming peptides rich in aspartic amino acids and of tricalcium phosphate (b-TCP)-loaded hydrogels on calcium adsorption and cell culture in vitro, and on bone regeneration in vivo. The hydrogels were found to act as efficient depots for calcium ions, and to induce osteoblast differentiation in vitro. In vivo studies on bone defectdoi:10.1016/j.actbio.2012.04.003 pmid:22503952 fatcat:cfbzhavogbg4lbjgz6r3d4mjyi