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Blood platelets from reserpinized rabbits produced a larger amount of malondialdehyde (M DA) in response to thrombin than the platelets from control rabbits. The MDA production was almost completely inhibited by aspirin and indomethacin, indicating that the MDA was produced through the cyclooxygenase pathway. When intracellular free Ca" was diminished by tetracaine or dibutyryl cyclic AMP, thrombin could not induce MDA production in the reserpinized or in the control platelets. Whendoi:10.2220/biomedres.3.6 fatcat:mnz6jtnfencxras3whdokxlmoi