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Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is an important intracellular mediator of stress signals. In this report, a novel target of MK2 has been identified, the ETS transcription factor family member ER81, whose dysregulation contributes to tumorigenesis and whose normal function is required during development. MK2 phosphorylates ER81 in vitro within its central inhibitory domain, and overexpression of MK2 leads to increased in vivo phosphorylation of ER81. Two serinedoi:10.1074/jbc.m106630200 pmid:11551945 fatcat:qh2gbo75jnez7lik6ifs34b22y