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Accessory proteins of HIV and innate anti-retroviral factors
The HIV genome encodes several accessory proteins (Vif, Vpr, Vpx, Vpu, and Nef) unique to primate lentiviruses, in addition to the structural (Gag, Pol, and Env) and regulatory (Tat and Rev) proteins. Early studies showed that deletion of accessory proteins has a small or no effect on virus replication in cell cultures. However, recent studies have clearly demonstrated that these proteins are essential for efficient viral replication, dissemination, pathogenicity, and disease progression. Here,doi:10.2222/jsv.59.67 pmid:19927991 fatcat:lojgpas7bjaxvh5eq6j2x2oeta