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Clonal hematopoiesis is driven by aberrant activation of TCL1A
[article]
2021
bioRxiv
pre-print
A diverse set of driver genes, such as regulators of DNA methylation, RNA splicing, and chromatin remodeling, have been associated with pre-malignant clonal expansion of hematopoietic stem cells (HSCs). The factors mediating expansion of these mutant clones remain largely unknown, partially due to a paucity of large cohorts with longitudinal blood sampling. To circumvent this limitation, we developed and validated a method to infer clonal expansion rate from single timepoint data called PACER
doi:10.1101/2021.12.10.471810
fatcat:o2b7qszeuvfoxmczmmangsniwa