Evaluation of D-Dimer Concentrations in Clinically Ill Dogs with High Risk of Thromboembolic Disease

Min-Hee Kang, Ra-Young Heo, Hee-Myung Park
Pakistan Veterinary Journal   unpublished
Many systemic and metabolic diseases are associated with increased risk factors that promote the development of thrombus. But early diagnosis of thromboembolism (TE) may difficult in general practice due to a lack of noninvasive diagnostic tests. This study was conducted to compare the plasma concentration of D-dimer, platelet numbers and fibrinogen degradation products (FDPs) between healthy and clinically ill dogs to evaluate the usefulness of these assays in detections of hypercoagulability.
more » ... Eighty-one clinically ill dogs with high risk of TE and 25 healthy dogs were included in this study. The plasma D-dimer concentrations were measured through the immunometric assay, and FDPs concentration was measured by semi-quantitative latex agglutination assay. Results of the present study indicated D-dimer concentrations were mainly elevated in immune-mediated hemolytic anemia (IMHA), liver disease, neoplasia and miscellaneous inflammatory disease group. In addition, markedly increased Ddimer concentrations (>2000ng/ml) were also mostly presented in IMHA (33.3%), liver disease (20%), and neoplasia (14.3%) group. Platelet numbers were significantly different only in neoplasia and endocrine disorder group. The plasma concentrations of D-dimer and FDPs of clinically ill dogs were mainly increased compared to healthy dogs. However, almost 30% of dogs with normal D-dimer value showed positive FDP assay results in both healthy and disease group. Concurrently performed plasma D-dimer and FDPs assays can be rapid screening tests for hypercoagulability in canine patients; however, cautious interpretation is required and should not be used as single diagnostic tool for TE. To Cite This Article: Kang MH, Heo RY and Park HM, 2016. Evaluation of D-dimer concentrations in clinically ill dogs with high risk of thromboembolic disease. Pak Vet J, 36(2): 219-223.