An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices

Chenyi Chen, Róger M. Martínez, Tsai-Tsen Liao, Chin-Yau Chen, Chih-Yung Yang, Yawei Cheng
<span title="2020-03-10">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="" style="color: black;">Communications Biology</a> </i> &nbsp;
The tonic model delineating the serotonin transporter polymorphism's (5-HTTLPR) modulatory effect on anxiety points towards a universal underlying mechanism involving a hyper-or-elevated baseline level of arousal even to non-threatening stimuli. However, to our knowledge, this mechanism has never been observed in non-clinical cohorts exhibiting high anxiety. Moreover, empirical support regarding said association is mixed, potentially because of publication bias with a relatively small sample
more &raquo; ... e. Hence, how the 5-HTTLPR modulates neural correlates remains controversial. Here we show that 5-HTTLPR short-allele carriers had significantly increased baseline ERPs and reduced fearful MMN, phenomena which can nevertheless be reversed by acute anxiolytic treatment. This provides evidence that the 5-HTT affects the automatic processing of threatening and non-threatening voices, impacts broadly on social cognition, and conclusively asserts the heightened baseline arousal level as the universal underlying neural mechanism for anxiety-related susceptibilities, functioning as a spectrum-like distribution from high trait anxiety non-patients to anxiety patients.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1038/s42003-020-0850-3</a> <a target="_blank" rel="external noopener" href="">pmid:32157156</a> <a target="_blank" rel="external noopener" href="">fatcat:lqkaap67ufem7jphm3hmrkf4hy</a> </span>
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