Abstracts A72 Arch Dis Child 2013;98(Suppl 1):A1-A117 factor for carbon monoxide (DLCO), functional residual capacity (FRCpleth) and maximum expiratory flow at 24, 50, 75% of vital capacity (MEF 25 , 50 , 75 ) were assessed. The results were expressed as z-scores. The response to a cold air challenge (CACh) was considered positive if FEV1 fell by >10% of baseline. Results At the time of assessment, compared to the non SGA children, the SGA children had lower weight (p < 0.001) and height (p =

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... 002). The SGA children had lower mean z-scores for FEV1 (p < 0.001), FEV1/FVC (P = 0.009), DLCO (p = 0.013), MEF 25 (p = 0.005), MEF 50 (p = 0.002) and MEF 75 (p < 0.001) and a higher mean FRCpleth z-score (p = 0.010). There was no significant difference regarding the proportion of SGA and non SGA children responding to a CACh (p = 0.091). Conclusion These results suggest that amongst very prematurely born children, being SGA at birth is associated with greater restrictive and obstructive (particularly of small airways) lung function abnormalities at school age. RefeRences 1. Peacock J, Marston L, Marlow N, et al Neonatal and infant outcome in boys and girls born very prematurely. Ped Res 2012; 71:305-310. 2. Johnson AH, Peacock JL, Greenough A, et al High frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity. New Engl J Med 2002; 347:633-642. sickle cell Disease in Malawian chilDRen is associateD with RestRictive spiRoMetRy: a cRoss sectional suRvey