Sealing Penetrating Eye Injuries With Photoactivated Bonding
[report]
Irene E. Kochevar
2013
unpublished
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... torate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. SUPPLEMENTARY NOTES ABSTRACT Purpose: To develop a light-activated technology with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. Scope: To establish, in ex vitro and in vivo animal models, the treatment parameters for sealing corneal and scleral penetrating wounds and to close lacerations in thin (eyelid-like) skin. To design and evaluate a prototype light delivery device. Major findings: We established that bonding amniotic membrane over penetrating cornea and scleral wounds produced immediate, water-tight seals that withstood an intraocular pressure of 350 mm Hg. We closed lacerations in eyelid-like skin with the dye + light treatment, which showed less inflammation than after sutured closure. A prototype light delivery system was designed, constructed and tested to deliver retina-safe light levels while providing light levels sufficient for sealing amniotic membrane over corneal wounds. Studies demonstrated that thermal damage to the iris is not a concern during these repair treatments.
doi:10.21236/ada591047
fatcat:lr3c5q7ewvftxmejoyff3xx47u