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Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials
1994
Psychological Medicine
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SYNOPSIS Effectiveness and side-effects of high-versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.
doi:10.1017/s003329170002729x
fatcat:jku6ik6fvfdnhhe77zfigvd42a