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Nucleus Accumbens Dopamine D3 Receptor Regulates Microglial M1 Polarization Through Akt Signaling Pathway in the Depressive-Like Behavior
[post]
2021
unpublished
Background: Nucleus accumbens (NAc) inflammation is implicated in the development and progression of depression but the underlying mechanism remains largely unclear. We previously reported that dopamine D3 receptor (D3R) expressed in the NAc strongly correlated with inflammation-related depression. The objective of the present study is to determine the exact mechanism of D3R in the NAc inflammation relevant depression.Methods: Bilateral NAc injection of Lipopolysaccharide (LPS)-induced NAc
doi:10.21203/rs.3.rs-433541/v1
fatcat:d3iegm3szje5zm66ktugqavdpi