FORMULASI DAN EVALUASI SEDIAAN TABLET ASAM MEFENAMAT MENGGUNAKAN EKSIPIEN CROSCARMELLOSE SODIUM SEBAGAI DISINTEGRAN DENGAN METODE GRANULASI BASAH

Jafar Garnadi
2019 Journal of pharmacopolium  
Mefenamic acid is a class of NSAIDs (Non-Steroid Antiinflammatory) which belongs to BCS group (Biopharmaceutical Classification System) class II that is low solubility with high penetration membrane. So it is necessary to increase the solubility to get absorption that can penetrate the maximum therapeutic zone of reagent. This study aims to determine the effect of the concentration of disintegran Croscarmellose sodium with a concentration of 1% -5% on the physical quality and dissolution rate
more » ... dissolution rate because it has a working mechanism of water absorption (water wicking) and swelling rapidly. Raw material collection, manufacture of mefenamic acid tablets (the wet granulation method is used because it can improve the flow rate and the compressibility of the mefenamic acid), evaluation of mefenamic acid granules, evaluation of mefenamic acid tablets, data analysis using one way ANOVA. Characterization of physical quality of granules moisture content, flow rate, fixed angle according to requirements. Characterization of quality tablet hardness, friability, frixibility, weight, uniformity size, disintegration time, and dissolution according to requirements.. Statistical analysis, indicating that there are significant differences in hardness, weight, uniformity of size, crushed time, rate and dissolution. From the results of this study can be concluded that the formula with a concentration of Croscarmellose Sodium 5% gives the best results. menunjukkan ada perbedaan bermakna. Hal tersebut menunjukkan adanya pengaruh penggunaan konsentrasi bahan penghancur yang berbeda pada setiap formula. Formula dengan kadar Croscarmellose sodium 5% (F6) merupakan formula dengan mutu fisik dan laju disolusi yang terpilih, karena mempunyai mutu fisik dan laju disolusi tablet yang memenuhi syarat. KESIMPULAN Kadar Croscarmellose sodium sebesar 5% (F6) merupakan formula terpilih dengan mutu fisik yang memenuhi persyatan dan laju disolusi yang optimal.
doi:10.36465/jop.v2i1.470 fatcat:ztg7u2li2rfbtp5w473anbspny