The Porphyrias are metabolic disorders, each resulting from the deficiency of a specific enzyme in the heme biosynthetic pathway. Acute intermittent porphyria (AIP) is an autosomal dominant inborn error characterized by decreased activity of porphobilinogen (PBG) deaminase leading to increased levels of haem precursors, namely amino levulinic acid (ALA) and PBG. The major manifestations of theacute hepatic porphyrias are neurologic-neuropathic abdominal pain, peripheral motor neuropathy, and

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... neuropathy, and mental disturbanceswith attacks often precipitated by steroid, hormones, certain drugs, and nutrition influences. Purpose: Intensive care measures and a multidisciplinary therapeutic approach are essentialbut thereis less documented evidence are available.If this aspect is incorporated early in the rehabilitation programme, then the functional recovery in such will be better.so the aim of the study is to find how Early Physiotherapy intervention using Comprehensive need based Approach to improve the functional status of porphyria patient. Key Points of Case: A 17 years old male patient wasdiagnosed with acute intermittent Porphyria. Having the history of abdominal pain since last 3 months with family history of AIP which was diagnosed very late. A detailed Physical and Neurological examination of this patient was taken. Along with medical treatment, early physiotherapy intervention using comprehensive need base approach was being given to the patient. The Barthel Index was taken to assess the functional status of the patient and Berg Balance Scale was taken to assess balance on admission and subsequent follow-ups. Post-intervention follow-ups were taken at 6 weeks and 12 weeks period. Conclusion: A clinically significant improvement was found on Barthel Index and Berg Balance Scale. Early Physiotherapy intervention using a Comprehensive need based Approach is highly recommended to improve the functional status of a patient with porphyria