Online) An Open Access

Ravikant Soni, Bushra Fiza, Rati Mathur, Maheep Sinha
2015 International Journal of Basic and Applied Medical Sciences   unpublished
In vitro fertilization (IVF) is a commonly performed assisted reproductive technology (ART) procedure which is being adopted by infertile couples across the world. Despite the proven benefits, IVF has a low success rate. Evaluation of different parameters at different stages of this treatment is helpful for the clinicians to identify patients with poor prognosis and to improve the overall success rate. The study was planned to systematically review the association between 17β Estradiol (E 2)
more » ... els on the day of βhCG administration and pregnancy achievement in IVF patients and also to assess whether fall or rise in E 2 is detrimental to pregnancy outcome. The study included 120 infertile female patients in the age range 25-40 years. The patients selected were subjected to standardized initial screening and baseline study between day 3-5 of menstrual cycle. Ovulation induction was done and when atleast 5 follicles had reached >14 mm of development, hCG (10000 IU/IM) was administered. On the same day, serum estradiol levels were measured and on its basis patients were grouped as (<1000; 1000-2500 & >2500pg/ml). The various steps of IVF protocol were performed and finally serum hCG was evaluated for chemical conformation of pregnancy and further after 15 days Transvaginalsonography was done for clinical conformation of pregnancy. A significantly higher pregnancy rate was observed in patients with E 2 level 1000-2500 pg/ml as compared to other groups. A rise or fall beyond it is detrimental for the success of IVF. Hence a specific range of serum 1000-2500 pg/ml is favorable for higher pregnancy rate in IVF patients.