Quantitative Mechanistically Based Dose-Response Modeling with Endocrine-Active Compounds

Melvin E. Andersen, Rory B. Conolly, Elaine M. Faustman, Robert J. Kavlock, Christopher J. Portier, Daniel M. Sheehan, Patrick J. Wier, Lauren Ziese
1999 Environmental Health Perspectives  
A wide range of toxicity test methods is used or is being developed for assessing the impact of endocrine-active compounds (EACs) on human health. Interpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically based dose-response (MBDR) models to assist low-dose, interspecies, and in vitro to in vivo extrapolations. A quantitative dose-response modeling work group examined the state of the art for developing
more » ... BDR models for EACs and the near-term needs to develop, validate, and apply these models for risk assessments. Major aspects of this report relate to current status of these models, the objectives/goals in MBDR model development for EACs, low-dose extrapolation issues, regulatory inertia impeding acceptance of these approaches, and resource/data needs to accelerate model development and model acceptance by the research and the regulatory community.
doi:10.2307/3434556 pmid:10421774 pmcid:PMC1567506 fatcat:7ugwuxttqrdivkmnyesapnh6ua