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Glucocorticoids have been belonged to the most widely and commonly used immune modulatory drugs in autoimmune and inflammatory conditions. The anti-inflammatory and immune suppressant mechanisms have been described. However, the glucocorticoids have paracrine and autocrine manner, acting at local tissue level and that is called as "tissue-specific" glucocorticoids. Those have a significant role in the development of inflammation. The glucocorticoid receptors, the sensitivity for glucocorticoidsdoi:10.4172/1745-7580.1000099 fatcat:mt4aaw6qyjhprmgkb2mtellbea