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Rebound Thrombocytosis following Induction Chemotherapy Is an Independent Predictor of a Good Prognosis in Acute Myeloid Leukemia Patients Attaining First Complete Remission

Umit Yavuz Malkan, Gursel Gunes, Ayse Isik, Eylem Eliacik, Sezgin Etgul, Tuncay Aslan, Muruvvet Seda Balaban, Ibrahim Celalettin Haznedaroglu, Haluk Demiroglu, Hakan Goker, Osman Ilhami Ozcebe, Nilgun Sayinalp (+2 others)
2015 Acta Haematologica  

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row capacity or late consolidation, we considered neutrophil recovery time and platelet recovery time and nadir-first consolidation durations in all patients in the cohort. Both the marrow recovery duration and the time between marrow aplasia and first consolidation were shorter in RT and RN patients. To our knowledge, this is the first study to report a correlation between RT/RN and prognosis in AML. Abstract There are very few data about the relationship between acute myeloid leukemia (AML)
more » ... ognosis and bone marrow recovery kinetics following chemotherapy. In this study, we aimed to assess the prognostic importance and clinical associations of neutrophil and platelet recovery rates and rebound thrombocytosis (RT) or neutrophilia (RN) in the postchemotherapy period for newly diagnosed AML patients. De novo AML patients diagnosed between October 2002 and December 2013 were evaluated retrospectively. One hundred patients were suitable for inclusion. Cox regression analysis using need for reinduction chemotherapy as a stratification parameter revealed RT as the only parameter predictive of OS, with borderline statistical significance (p = 0.06, OR = 7; 95% CI 0.92-53), and it was the only parameter predictive of DFS (p = 0.024, OR = 10; 95% CI 1.3-75). In order to understand whether RT or RN was related to a better mar-
doi:10.1159/000369917 pmid:25872012 fatcat:mxxuzz57jjfvngfqqvui2bf43e
Citation

Umit Yavuz Malkan, Gursel Gunes, Ayse Isik, Eylem Eliacik, Sezgin Etgul, Tuncay Aslan, Muruvvet Seda Balaban, Ibrahim Celalettin Haznedaroglu, Haluk Demiroglu, Hakan Goker, Osman Ilhami Ozcebe, Nilgun Sayinalp, Salih Aksu, Yahya Buyukasik. "Rebound Thrombocytosis following Induction Chemotherapy Is an Independent Predictor of a Good Prognosis in Acute Myeloid Leukemia Patients Attaining First Complete Remission." Acta Haematologica 134.1 (2015) 32-37