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Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse

Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland (+16 others)
2021

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https://web.archive.org/web/20210311023536/https://www.repository.cam.ac.uk/bitstream/handle/1810/318521/Neural%20network%20involving%20medial%20orbitofrontal%20cortex%20and%20dorsal%20periaqueductal%20gray%20regulation%20in%20human%20alcohol%20abuse.pdf;jsessionid=EF9963CCA38B1E744063257152B3B928?sequence=1

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Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was
more » ... dentified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.
doi:10.17863/cam.65635 fatcat:tayww253bffjfisatbldfmp72e
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Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor Robbins, Jianfeng Feng, IMAGEN Consortium, Apollo-University Of Cambridge Repository. "Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse." (2021)