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Faculty of 1000 evaluation for Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
F1000 - Post-publication peer review of the biomedical literature
Urinary exosomes or microvesicles are being studied intensively to identify potential new biomarkers for renal disease. We sought to identify whether these microvesicles contain nucleic acids. We isolated microvesicles from human urine in the same density range as that previously described for urinary exosomes and found them to have an RNA integrity profile similar to that of kidney tissue, including 18S and 28S rRNA. This profile was better preserved in urinary microvesicles compared withdoi:10.3410/f.3196956.2884054 fatcat:ipyqxcaoqncmlaixd4qqg5ug2e