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Umbrella Visualization: a method of analysis dedicated to glycan flexibility with UnityMol
2019
Methods
N-glycosylation is a post-translational modification heavily impacting protein functions. Some alterations of glycosylation, such as sialic acid hydrolysis, are related to protein dysfunction. Because of their high flexibility and the many reactive groups of the glycan chains, studying glycans with in vitro methods is a challenging task. Molecular dynamics is a useful tool and probably the only one in biology able to overcome this problem and gives access to conformational information through
doi:10.1016/j.ymeth.2019.07.010
pmid:31302178
pmcid:PMC7128144
fatcat:fdgcs35cbrg3rpwotmkio3hnxe