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Histone deacetylase inhibitors (HDACi), such as trichostatin A (TSA), can regulate gene expression by promoting acetylation of histones and transcription factors. Human tissue factor (TF) expression is partly governed by a unique, NF-B-related "TF-B" promoter binding site. We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by ϳ90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologicdoi:10.1074/jbc.m703586200 pmid:17675290 fatcat:7xfhylkcpfh67bbx2bfkrhk4vq