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Individuals carrying the *E4 allele of the apolipoprotein E gene (APOE) are at increased risk of developing Alzheimer's disease (AD). However, the biological mechanisms underlying this association are still unclear because of the complexity of the pathological processes that cause AD. Furthermore, the effect of APOE genotype on development, maintenance and aging of the normal brain is poorly understood because of the strong bias toward studying disease associations. In vivo techniques such asdoi:10.1016/j.neubiorev.2013.05.006 pmid:23701948 fatcat:js4cp5zvjrfpnf7elnq6g3jcky