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APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease
2013
Neuroscience and Biobehavioral Reviews
Individuals carrying the *E4 allele of the apolipoprotein E gene (APOE) are at increased risk of developing Alzheimer's disease (AD). However, the biological mechanisms underlying this association are still unclear because of the complexity of the pathological processes that cause AD. Furthermore, the effect of APOE genotype on development, maintenance and aging of the normal brain is poorly understood because of the strong bias toward studying disease associations. In vivo techniques such as
doi:10.1016/j.neubiorev.2013.05.006
pmid:23701948
fatcat:js4cp5zvjrfpnf7elnq6g3jcky