Sirolimus: a new promising immunosuppressive drug. Towards a rationale for its use in renal transplantation

Emmanuel Morelon, Marie‐France Mamzer‐Bruneel, Marie‐Noëlle Peraldi, Henri Kreis
2001 Nephrology, Dialysis and Transplantation  
Keywords: immunosuppressive drugs; rapamycin; renal IL4, in an autocrine or paracrine fashion. It also drives competent T-cell entry into the proliferation cycle via transplantation; sirolimus progression from the G1 to the S phase, with subsequent clonal expansion and the acquisition of T-cell effector functions.
doi:10.1093/ndt/16.1.18 pmid:11208987 fatcat:fjluswcuwve3hbhd3aacmyuh3u