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HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons
2019
eLife
Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical rhythmicity and excitability in the heart and brain, but the function of HCN channels at the subcellular level in axons remains poorly understood. Here, we show that the action potential conduction velocity in both myelinated and unmyelinated central axons can be bidirectionally modulated by a HCN channel blocker, cyclic adenosine monophosphate (cAMP), and neuromodulators. Recordings from mouse cerebellar
doi:10.7554/elife.42766
pmid:31496517
pmcid:PMC6733576
fatcat:55mr6siufvawbc2hoqjeutu6wm