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Background: There is a paucity of data on the knowledge and practice of preventive measures for Hepatitis E infection. Determination of knowledge and practice of preventive measures are necessary for informed health education for the prevention of Hepatitis E infection and other communicable diseases. The study evaluated the prevalence of Hepatitis E, knowledge, and practice of preventive measures for Hepatitis E virus infection among adolescents in rural Nigeria.Methods: This cross-sectionaldoi:10.21203/rs.3.rs-243925/v1 fatcat:4le7alwqp5bqdbghpiuaugnzlm