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Purpose of the investigation: Insulin receptor (IR) may play an essential role in the development of beta cell mass in the mouse pancreas. To further define the function of this signaling system in beta cell development, we have generated IR-deficient beta cell lines. Methods: Fetal pancreata were dissected from mice harboring a floxed allele of the insulin receptor (IRLoxP) and used to isolate islets. These islets were infected with a retrovirus to express SV40 large T antigen, a strategy fordoi:10.1210/en.2005-0831 pmid:16396989 fatcat:im3qtvqty5bltns7iewomttqqi