A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
2018
eLife
Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium.
doi:10.7554/elife.38588
pmid:30355449
pmcid:PMC6235562
fatcat:jxfqrnpaf5chriobuao46mbsma