Analysis of Risk Factor for Anastomotic Leakage after Lower Rectal Cancer Resection, Including Drain Type: A Retrospective Single-Center Study [post]

Tetsushi Kinugasa, Sachiko Nagasu, Kenta Murotani, Tomoaki Mizobe, Takafumi Ochi, Taro Isobe, Fumihiko Fujita, Yoshito Akagi
2020 unpublished
Abstract Background: We investigated the correlations between surgery-related factors and the incidence of leakage after low anterior resection (LAR) for lower rectal cancer. Methods: A total of 630 patients underwent colorectal surgery between 2011 and 2014 in our department. Of these, 97 patients (15%) underwent LAR and were included in this retrospective study. Temporary ileostomy was performed in each patient. Results: Anastomotic leakage occurred in 21 patients (21.7%). Univariate analysis
more » ... Univariate analysis showed that operative duration (p=0.005), transanal hand-sewn anastomosis (p=0.014), and operation procedure (p=0.019) were significantly associated with the occurrence of leakage. Multivariate analysis showed that underlying disease (p=0.044), transanal hand-sewn anastomosis (p=0.019) and drain type (p=0.025) were significantly associated with the occurrence of leakage. Propensity-score analysis showed that closed drainage were 6.3 times more likely to have anastomotic leakage than open drainage in relation to the amount of postoperative drainage (ml), according to inverse probability of treatment-weighted analysis . Conclusions: Our results indicate that underlying disease, transanal hand-sewn anastomosis, and drain type may be risk factors for anastomotic after LAR for lower rectal cancer. The notable finding was that the type of drainage was related to the occurrence of anastomotic leakage: closed drainage was correlated with the less volume of postoperative drain discharge than open drain.
doi:10.21203/rs.2.24606/v3 fatcat:oje5lnzmovccnasipswnm5le5a