Stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to HPA axis [article]

Qi Zhengtang, Jie Xia, Xiangli Xue, Jiatong Liu, Xue Zhang, Xingtian Li, Wenbin Liu, Lu Cao, Lingxia Li, Zhiming Cui, Zhuochun Huang, Benlong Ji (+3 others)
2019 bioRxiv   pre-print
Inhibiting glycemic response to HPA axis contributes to glycemic control for diabetic patients. Here, mice were subjected to high-fat diet and intermittent chronic stress, and glucose homeostasis and lipolysis were determined during the intervention. Firstly, we found that glucose intolerance appears at the earliest, followed by reduced insulin sensitivity and increased epinephrine (EPI) sensitivity in the early stage of diet-induced obesity. Next we investigated whether chronic stress impairs
more » ... nic stress impairs glycemic control and which mediates its effects. Short-term stress training raises serum and skeletal muscle myonectin (Myn) levels and improves glucose intolerance. Stress attenuates blood glucose and glycerol responses to EPI, but enhances lipolytic response to EPI in adipose tissues. Myn overexpression in vivo improves glucose tolerance and enhances insulin sensitivity at the cost of blunting glycemic responses to EPI. Myn knockdown reduces beneficial effects of stress or exercise on glucose homeostasis. Together, myonectin is a stress-induced myokine that readjusts glycemic and metabolic responses to HPA axis, and thus prevent the progression of glucose intolerance and obesity.
doi:10.1101/838003 fatcat:hwlxeesvnraujherg6467yx6h4