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Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study
Asian Pacific Journal of Cancer Prevention
Purpose: To evaluate effects of metformin on clinical outcome of non-diabetic patients with stage IV NSCLC. Materials and Methods: A prospective, randomized, open-label, controlled pilot study was conducted on patients with stage IV NSCLC with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2, excluding patients with diabetes and lactic acidosis. Thirty chemo-naïve, non-diabetic patients with stage IV NSCLC were enrolled. Fifteen patients received intravenousdoi:10.7314/apjcp.2015.16.15.6621 fatcat:vzefsal2o5f7nn7c4ixelvutsm