HIV-Associated Multiple Intracerebral Hemorrhages

Martin Liebetrau, Markus Holtmannspötter, Viktor Arbusow, Gerhard F. Hamann
2005 European Neurology  
type distribution or allelic frequency when comparing AD patients with normal controls. From the analysis of age at AD onset, no signifi cant difference was determined when comparing the three A2aAR 1976T 1 C genotype groups. Therefore, it is unlikely that the A2aAR 1976T 1 C polymorphism plays an important role in the pathogenesis of AD. In this study, the size of effect that could be detected with 80% power at the 5% signifi cance level is odds ratio of 1.6 for AD. Since AD probably has
more » ... probably has multiple determinants, and if A2aAR is an uncommon disease locus or one of small effect, our power to detect a genetic effect would be reduced. Furthermore, negative fi ndings for one polymorphism may not exclude the involvement of the locus as a whole. Before a role of the A2aAR gene in the etiology of AD can be defi nitely excluded, further studies using haplotype analysis to investigate multiple polymorphisms in the A2aAR gene in AD are needed.
doi:10.1159/000085510 pmid:15855784 fatcat:fmjldue5wzhsrgqpbpp2vgyupe