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Objective: Heparins can interfere with lupus anticoagulant (LA) testing, especially when the detection assays do not contain a heparin neutralizer. In this study we evaluated whether hexadimethrine bromide commonly known as polybrene was able to neutralize the effects of unfractionated heparin (UFH) on activated partial thromboplastin time (aPTT)-based LA determination. Material and Methods: The influence of polybrene on the aPTT-based LA testing results of 14 patients receiving UFH therapy wasdoi:10.31584/jhsmr.2022913 fatcat:dq7ujoabojdcriiplijgndvmji