A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
Establishment of Primary Culture Models of Multiple System Atrophy Based on Expression of a-Synuclein in Oligodendrocytes
Multiple system atrophy (MSA) is a neurodegenerative syndrome characterized by (oligodendro)glial cytoplasmic inclusions (GCIs) composed of a-synuclein. I have developed cell culture models of MSA based on overexpression of human a-synuclein in primary mouse oligodendrocytes. In oligodendrocytes derived from (PLP)-a-synuclein transgenic mice, elevation of a-synuclein levels by proteasome inhibition induced GCI formation and enhanced apoptosis. The same effects were observed in wild-typedoi:10.5282/edoc.12929 fatcat:i2ize2ulzzbm5hehdfmrrb4qya