Synthesis and Biological Activity of some New Nitrogenous Heterocyclic Compounds Derived from Azachalcone

Hamad J. Jumaa, Munera Y. Roof, Shakir M. Saied
2019 Rafidain journal of science  
ABCTRACT A series of heterocyclic compounds containing oxygen and nitrogen atoms, isoxazoline ІI(a-d) and another containing two nitrogen atoms, pyrazolinesІII(a-d) and phenylpyrazolines IV(a-d) were prepared by the reaction of a proper azachalcones І(a-d) with hydroxylaminehydrochloride, hydrazine hydrate or phenylhydrazine. These heterocyclic compounds were characterized by 1 H-NMR , CHN , IR and UV spectra in addition to their some physical properties. Also, these prepared compounds were
more » ... ened for their biological activities and a theoretical calculation which shows that the product IVa obtained from 1,2 -rout was energetically more stable by 1.3967 kcal/mole than that came from 1,4rout, thus the reaction proceed via 1,2 -addition.
doi:10.33899/rjs.2019.159977 fatcat:vhtwikbmz5eaxe6rpglgbnseva