OC-0250: Hadrontherapy as re-irradiation using active beam delivery at CNAO

E. Ciurlia, M. Bonora, P. Fossati, V. Vitolo, A. Iannalfi, M. Fiore, B. Vischioni, A. Facoetti, A. Hasegawa, F. Valvo, M. Krengli, R. Orecchia
2016 Radiotherapy and Oncology  
data on 138 children (78 males, 60 females, aged 0.9-17.9 years (median 5.7 years)) were prospectively collected in KiProReg at WPE. Diagnoses were CNS tumours (n=73), sarcomas (n=59), extracranial germ cell tumors (n=3) and others (n=3), respectively. Treatment sites were brain (n=72), head and neck including base of skull (n=38), spine (n=15), or pelvis (n=13). In 73.9% of the patients, macroscopic residual disease was present before PT. The median total dose of PT was 54.0 Gy (range
more » ... Gy (range 29.8-74.0 Gy). Only two patients had a mixed beam technique. Due to the very young age, sedation was necessary in 55.1% of children. Concurrent chemotherapy was applied in 54.3% of children. Side-effects were classified according to Common Terminology Criteria for Adverse Events (CTCAE) V4.0 grading system. Results: Median follow-up (FU) since first diagnosis was 1.2 years (range 0.3-16.3 years). PT was well tolerated. No or only mild to moderate acute side-effects (grade 1 to 2) were documented in the majority of children (n=116). During PT, acute grade 3 side-effects were observed for blood/bone marrow (n=21), gastrointestinum (n=8) or as general disorders (n=3) as well as anorexia (n=1) when compared to baseline. Acute grade 4 side-effects during PT were only seen for blood/bone marrow (n=9). In 77 children, information on toxicity three months after PT is available. Only few patients presented with grade 3 or 4 toxicities, predominantly for blood/bone marrow (grade 3 n=7, grade 4 n=2). Seven of them had received chemotherapy after PT. So far, 17 patients failed due to recurrence or progression (local n=5; systemic n=12). Six of them (4.3%) have died so far, all due to disease.
doi:10.1016/s0167-8140(16)31499-2 fatcat:idys63gctvehbfrxweuvc2pyn4