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Advances in Experimental Medicine and Biology
MicroRNAs can affect the protein translation using nine mechanistically different mechanisms, including repression of initiation and degradation of the transcript. There is a hot debate in the current literature about which mechanism and in which situations has a dominant role in living cells. The worst, same experimental systems dealing with the same pairs of mRNA and miRNA can provide ambiguous evidences about which is the actual mechanism of translation repression observed in the experiment.doi:10.1007/978-94-007-5590-1_11 pmid:23377975 fatcat:qeqpfulzbbfoza4cgqwonof76q