SOC channel is the main calcium signal channel in T cells and osteoclast cells. Previous studies indicate that early activation of osteoclast relies on calcium entry through store-operated calcium entry (SOCE). Knockdown the expression of STIM1 in osteoclast will diminish their differentiation. Orai1-/-mice also shows significantly decrease in cortical ossification. Inositol-trisphosphate 3-kinase C (ITPKC) is a negative regulator of the SOC channel. However, the relation between STIM1, Orai1,

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... TPKC and bone mineral density (BMD) are still unclear. In order to investigate the plausible association with SOCE genes and BMD, we conducted a meta-analysis of genes expression and BMD using publicly available GEO database. We further recruited a total of 1044 subjects and tested the association between the polymorphism of these genes and BMD. Clinical information (including age, sex, and BMI) was collected and used for the analysis. Our results indicated that the gene expression of ITPKC was significantly associated with BMD. Furthermore, we found that one SNPs (rs2607420) of ITPKC was significantly associated with lumbar spine BMD. Through bioinformatics analysis, rs2607420 was a candidate that involved in the regulation of ITPKC expression. Our findings suggest that ITPKC is a susceptibility gene for BMD, and rs2607420 may play an important role in the regulation of this gene. Poster session WCP2018