LONGEVITY KLOTHO GENE POLYMORPHISM AND THE RISK OF DEMENTIA IN OLDER MEN

L. Flicker, B. Morar, G. Hankey, B. Yeap, J. Golledge, A. Jablensky, O. Almeida
2017 Innovation in aging  
High-performance were defined from the low-performance by improved FAI status or remaining within the upper most two quartiles. Significant variables in univariate analysis were further analyzed using logistic regression to ascertain predictors of improved FAI status. Results: At 2-year, there were 57(39%) high and 89(61%) low performance (FAI: 2.49 ± 3.39 vs -3.62 ± 4.41,p<0.01). High-performance maintained outdoor/indoor work (p<0.01) and indoor leisure (p=0.198) activities. Highperformance
more » ... clined in outdoor leisure activities, although of lesser degree than low-performance (-2.23 ± 2.24 vs -4.53 ± 2.45,p<0.01). Using logistic regression adjusted for gender, VRFs, SPPB and mood, living alone [OR=4.02, 95% CI:1.40-11.50] and younger age [OR=0.937, 95% CI:0.89-0.99] were predictors of improved FAI status. Conclusion: About two-fifths of community-dwelling older adults, typically those younger and living alone, maintained good activity participation at 2 years. While work activities were maintained, outdoor leisure participation notably declined. Further studies are needed to ascertain how living alone promotes maintenance of activity participation.
doi:10.1093/geroni/igx004.3247 fatcat:hf3s5rhoqfcwbk7twalc2wsf2m