Computer-aided breast cancer diagnosis in mammography is limited by inadequate data and the similarity between benign and cancerous masses. To address this, we propose a signed graph regularized deep neural network with adversarial augmentation, named DiagNet. Firstly, we use adversarial learning to generate positive and negative mass-contained mammograms for each mass class. After that, a signed similarity graph is built upon the expanded data to further highlight the discrimination. Finally,

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... deep convolutional neural network is trained by jointly optimizing the signed graph regularization and classification loss. Experiments show that the DiagNet framework outperforms the state-of-the-art in breast mass diagnosis in mammography.