Epigenética del síndrome de ovario poliquístico

Francisca Concha C., Teresa Sir P., Sergio E. Recabarren, Francisco Pérez B.
2017 Revista médica de Chile (Impresa)  
Epigenetics of polycystic ovary syndrome Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been
more » ... olved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity. (Rev Med Chile 2017; 145: 907-915)
doi:10.4067/s0034-98872017000700907 pmid:29182200 fatcat:w4654rxcdbf5niw5axpkeddsie