Phosphoramidates: Molecular Packing and Hydrogen Bond Strength in Compounds Having a P(O)(N)n(O)3-n (n = 1, 2, 3) Skeleton [chapter]

Mehrdad Pourayoubi, Fahimeh Sabbaghi, Vladimir Divjakovic, Atekeh Tarahhomi
2012 Advances in Crystallization Processes  
Phosphoramidates: Molecular Packing and Hydrogen Bond Strength in Compounds Having a P(O)(N) n (O) 3-n (n = 1, 2, 3) Skeleton 559 Scheme 3. The classification of compounds having a P(O)(N) n (O) 3-n (n = 1, 2, 3) skeleton which the salt is as precipitate (and the product is soluble) and then the filtering off the salt. Moreover, if more than twice mole ratio of amine relative to each P-X bond is used, removing the un-reacted amine should be done in the purification process, too, which may be
more » ... oo, which may be performed by stirring the crude product in a diluted hydrochloric acid [65] . Setzer and co-workers reported the synthesis of 1,3,2-oxazaphospholane from the reaction between (lR,2R)-(-)-pseudoephedrine, phenyl dichlorophosphate and triethylamine in ethyl acetate. Triethylamine hydrochloride was filtered off and the solvent removed from the filtrate under reduced pressure [66] .
doi:10.5772/35730 fatcat:zgjxetslhvdxnf4wdarlf7dnpm