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Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellular sensitivity to dopamine agonists remain poorly understood. In the present study, we examined the agonist-induced regulation of the human D2 L receptor expressed to a specific activity of ϳ1 pmol receptor/mg protein in Sf9 insect cells. Treatmentdoi:10.1210/en.138.10.4199 pmid:9322930 fatcat:tt47tpeakffc7kcn33ivh3x4ha