Assessment of thyroid dysfunction in beta thalassemia patients

Dr. Nagendra Singh Chauhan
2021 International Journal of Advanced Research in Medicine  
Thalassemia is the most common inherited monogenic disorder in the world. The present study was conducted to assess thyroid dysfunction in thalassemia patients. Materials & Methods: 84 children with beta thalassemia major of both genders were assessed for serum total thyroxine (T4), thyroid-stimulating hormone (TSH) and Serum ferritin levels were obtained. TSH and T4 concentration were analyzed by ELISA. Results: There were 64 euthyroid and 20 hypothyroid patients. 40 male and 24 females
more » ... id patients and 12 males and 8 hypothyroid patients. The difference was significant (P< 0.05). The amount of blood transfused was 230.4 ml/kg and 272 ml/kg, serum ferritin (ng/ml) level was 1972.5 and 28.16, serum TSH µIU/ml was 3.05 and 7.14, serum free T4 (pmol/l) was 12.7 and 10.6 and serum free T3 (pmol/l) level was 6.14 and 4.52 in euthyroid and hypothyroid patients. The difference was significant (P< 0.05). Conclusion: Severity of thyroid dysfunction in thalassemia patients was variable.
doi:10.22271/27069567.2021.v3.i1e.150 fatcat:kp7pshhu7nhohati3gkg7eidpe