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Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1
PYRIN-containing apoptotic protease-activating factor 1-like proteins (PYPAFs, also called NALPs) participate in inflammatory signaling by regulating nuclear factor-kB (NF-kB) activation and cytokine processing, and have been implicated in autoimmune and inflammatory disorders. However, the precise mechanisms that regulate the signal pathway leading to NF-kB activation are not completely understood. Here, we used yeast two-hybrid assays to identify Fas-associated factor 1 (FAF1) as a proteindoi:10.1093/intimm/dxl104 pmid:17046979 fatcat:oc24oi7bfbbtfaulcmz3f4s5za