Purpose: To report a mini review on novel biomaterials applied for ocular surface regeneration. Methods: A systematic review of the literature. Results: Human-derived amniotic membrane is the most preferred biomaterial to regenerate ocular surface because of its ease of access and low immunogenicity. Whereas, biological instability, lack of optimized preparation protocols, and risk of transmission of infection are still major issues that make its use controversial. Human blood-derived

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... ls have gained popularity to reconstruct and regenerate the ocular surface with a really basic principle and even low cost. Platelet-rich plasma (PRP) and platelet-rich-fibrin (PRF) are the two types of platelet enriched biomaterials that have been using in various clinical fields to improve wound healing via their excellent chemotactic and physical properties. Autologous biomaterials obtained from blood can be used in order to regenerate ocular surface. Conclusion: This review explores critical needs in ocular surface problems where conventional therapies are not well suited and the current demand to overcome corneal blindness.