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Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies
2011
Clinical Cancer Research
Purpose: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and iron overload is a significant risk factor in the development of HCC. In this study, we investigated the potential application of depriving iron by a novel iron chelator, thiosemicarbazone-24 (TSC24), in HCC treatment. Experimental Design: Two HCC cell lines and HFE knockout (HFE À/À ) mice were used to determine iron chelation efficiency of TSC24. The anticancer effects of TSC24 on HCC were
doi:10.1158/1078-0432.ccr-10-3099
pmid:22052937
fatcat:7wpkqtx5xzdi7m47myyr7dhe3e